Tirzapetide is a GL-1 and GL-2 inhibitor which means it has a dual action to help you achieve weight loss goals and glucose control. It works by delaying gastric emptying after you eat so you feel full longer, increases insulin secretion after a meal, and expels excess sugar into the urine.
Tirzapetide can cause G.I. side effects which may or may not include nausea, diarrhea, constipation, gas, abdominal pain, reflux, vomiting, and low blood sugar (hypoglycemia). Often these side effects diminish after a few weeks of use of Tirzapetide. Serious, but less common, reactions to Tirapetide may include thyroid cancer, pancreatitis, gallstones, and/or kidney problems.
Tirzapetide is given with a very small subcutaneous injection once per week. Every 4 weeks we will weigh you and gradually increase the amount you take until you reach a suitable dosage, healthy weight, and BMI.
In STEP 2, 68-week treatment with semaglutide at a dose of 2.4 mg reduced the absolute body weight by 9.7 kg, which corresponded to a 9.6% decrease from baseline (Fig. 1).12 The estimated treatment difference (ETD) of semaglutide 2.4 mg was 2.7% and 6.2% compared to semaglutide 1.0 mg and placebo, respectively.12 SURPASS-1 revealed that tirzepatide 15 mg at week 40 displayed 9.5 kg of absolute weight loss with a 10.1% greater decrease than placebo.15 Injection of tirzepatide at 15 mg for the same duration lowered the body weight by 13.1% in SURPASS-2 with an ETD of 6.4% compared to semaglutide 1 mg treatment.16
